Prediction of protein secondary structures from conformational biases
نویسندگان
چکیده
منابع مشابه
Prediction of protein secondary structures from conformational biases.
We use LINUS (the "Local Independently Nucleated Units of Structure"), a procedure developed by Srinivasan and Rose, to provide a physical interpretation of and predict the secondary structures of proteins. The secondary structure type at a given site is identified by the largest conformational bias during short simulations. We examine the rate of successful prediction as a function of temperat...
متن کاملPhysicochemical Position-Dependent Properties in the Protein Secondary Structures
Background: Establishing theories for designing arbitrary protein structures is complicated and depends on understanding the principles for protein folding, which is affected by applied features. Computer algorithms can reach high precision and stability in computationally designing enzymes and binders by applying informative features obtained from natural structures. Methods: In this study, a ...
متن کاملPrediction of protein conformational freedom from distance constraints.
A method is presented that generates random protein structures that fulfil a set of upper and lower interatomic distance limits. These limits depend on distances measured in experimental structures and the strength of the interatomic interaction. Structural differences between generated structures are similar to those obtained from experiment and from MD simulation. Although detailed aspects of...
متن کاملPrediction of Protein Conformational Freedom From Distance Constraints
A method is presented that generates random protein structures that fulfil a set of upper and lower interatomic distance limits. These limits depend on distances measured in experimental structures and the strength of the interatomic interaction. Structural differences between generated structures are similar to those obtained from experiment and from MD simulation. Although detailed aspects of...
متن کاملConsensus Prediction of Protein Conformational Disorder from Amino Acidic Sequence
Predictions of protein conformational disorder are important in structural biology since they can allow the elimination of protein constructs, the three-dimensional structure of which cannot be determined since they are natively unfolded. Here a new procedure is presented that allows one to predict with high accuracy disordered residues on the basis of protein sequences. It makes use of twelve ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 2002
ISSN: 0887-3585,1097-0134
DOI: 10.1002/prot.10124